Prostate cancer-associated transcript 6 (PCAT6) promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer

In this study, we find that elevated expression of PCAT6 is independently linked to unfavourable survival outcomes in The Cancer Genome Atlas (TCGA) data, and this finding is further confirmed in CRC samples obtained from Fudan University Shanghai Cancer Center. Cell lines and xenograft mouse models are used to examine the impact of PCAT6 on tumor metastasis. Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC, as evidenced by functional assays, demonstrating the suppression of epithelial-mesenchymal transition (EMT) and stemness. Our findings show the significance of PCAT6 in mCRC and its potential use as a prognostic biomarker.PMID:38606479 | DOI:10.3724/abbs.2024031

Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Xun Sun Yitao Yuan Suyao Li Lu Gan Midie Xu Qingguo Li Mengling Liu Keshu Hu Ke Nan Jiayu Zhang Yu Dong Yufu Lin Xiuping Zhang Pengcong Hou Tianshu Liu Source Type: research