Characteristic Fingerprint Spectrum of α-Synuclein Mutants on Terahertz Time-Domain Spectroscopy

CONCLUSION: The SNCA wild-type protein and two mutant variants (A30P and A53T) had distinct characteristic fingerprint spectra on THz time-domain spectroscopy. This novel label-free detection method has great potential for the differential diagnosis of Parkinson's disease subtypes.PMID:38615192 | DOI:10.1016/j.bpj.2024.04.011
Source: Biophysical Journal - Category: Physics Authors: Source Type: research