Linagliptin decreased the tumor progression on glioblastoma model

CONCLUSION: Inhibition of DPP-4 by linagliptin showed the antitumor effect on GBM cells and the murine GBM model. The antitumor effects of linagliptin is suggested to be based on the changes in the expression of several proteins related to cell cycle and cell adhesion via the regulation of phosphorylated NF-kB. This study suggested that DPP-4 inhibitors could be a new therapeutic strategy for GBM.PMID:38608433 | DOI:10.1016/j.bbrc.2024.149897
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research