Exploring volumetric abnormalities in subcortical L-HPA axis structures in pediatric generalized anxiety disorder

CONCLUSION: The BLA, vSC, and MDm are believed to be involved in the regulation of anxiety and stress, both individually and collectively through the excitation and inhibition of the L-HPA axis. All were found to be enlarged in children with GAD, perhaps reflecting hypertrophy related to hyperexcitability, or early neuronal overgrowth. Longitudinal studies should investigate the relationship between these early morphological differences and the long-term subcortical atrophy previously observed.PMID:38573199 | DOI:10.1080/08039488.2024.2335980
Source: Nordic Journal of Psychiatry - Category: Psychiatry Authors: Source Type: research