The Proteasome Inhibitor Carfilzomib exerts anti-inflammatory and anti-thrombotic effects on the endothelium

CONCLUSION(S): This data demonstrates that CFZ is unable to induce ER stress in confluent resting endothelial cells and can conversely attenuate the pro-thrombotic effects of TNFα on the endothelium. This study suggests that CFZ does not negatively alter HUVECs, and proteasome inhibition of the endothelium may offer a potential way to prevent thrombosis.PMID:38608731 | DOI:10.1016/j.jtha.2024.03.024

Source: Thrombosis and Haemostasis - April 12, 2024 Category: Hematology Authors: Ahmed Hjazi Celia Gonzalez Maroto Michael Appiah Maria Elena Rodriguez-Gutierrez Ana Ignat Golzar Mobayen Theresa Page Thomas A J McKinnon Source Type: research