Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology

CONCLUSIONS: In summary, the results of this study suggest that the CAR-T cells derived from high specificity and high affinity Nbs, targeting FGFR4, exhibited significantly enhanced anti-tumor efficacy in vitro and in vivo. This is an exploration of FGFR4 in the field of Nb-derived CAR-T cell therapy for HCC, holding promise for enhancing safety and effectiveness in the clinical treatment of HCC in the future.PMID:38610029 | DOI:10.1186/s12967-024-05159-x

Source: Cancer Control - April 12, 2024 Category: Cancer & Oncology Authors: Keming Lin Baijin Xia Xuemei Wang Xin He Mo Zhou Yingtong Lin Yidan Qiao Rong Li Qier Chen Yuzhuang Li Jinzhu Feng Tao Chen Cancan Chen Xinyu Li Hui Zhang Lijuan Lu Bingfeng Liu Xu Zhang Source Type: research