Targeting PNPO to suppress tumor growth via inhibiting autophagic flux and to reverse paclitaxel resistance in ovarian cancer

In conclusion, PNPO has a regulatory effect on lysosomal biogenesis that in turn promotes autophagic flux, leadin g to OC cell proliferation, and tumor formation, and is a paclitaxel-resistant factor. These data imply a potential application by targeting PNPO to suppress tumor growth and reverse PTX resistance in OC.
Source: Apoptosis - Category: Molecular Biology Source Type: research