Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers

Expert Rev Mol Med. 2024 Apr 12;26:e8. doi: 10.1017/erm.2024.7.ABSTRACTOsteoarthritis (OA) commonly affects the knee and hip joints and accounts for 19.3% of disability-adjusted life years and years lived with disability worldwide (Refs , ). Early management is important in order to avoid disability uphold quality of life (Ref. ). However, a lack of awareness of subclinical and early symptomatic stages of OA often hampers early management (Ref. ). Moreover, late diagnosis of OA among those with severe disease, at a stage when OA management becomes more complicated is common (Refs , , , ). Established risk factors for the development and progression of OA include increasing age, female, history of trauma and obesity (Ref. ). Recent studies have also drawn a link between OA and metabolic syndrome, which is characterized by insulin resistance, dyslipidaemia and hypertension (Refs , ).PMID:38606593 | DOI:10.1017/erm.2024.7

Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Shi Rui Seow Sumaiyah Mat Amalina Ahmad Azam Nor Fadilah Rajab Intan Safinar Ismail Devinder Kaur Ajit Singh Suzana Shahar Maw Pin Tan Francis Berenbaum Source Type: research