Augmenting external control arms using Bayesian borrowing: a case study in first-line non-small  cell lung cancer

Conclusion: In this study, the RWD ECA was unable to successfully replicate the OS estimates from the matched population of the selected RCT. The inability to replicate could be due to unmeasured confounding and variations in time-periods, follow-up and subsequent therapy. Despite these findings, we demonstrate how BB can improve precision of comparative effectiveness estimates, potentially aid as a bias assessment tool and mitigate challenges of traditional methods when appropriate external data sources are available.PMID:38573331 | DOI:10.57264/cer-2023-0175

Source: Journal of Comparative Effectiveness Research - April 4, 2024 Category: General Medicine Authors: Alessandria Struebing Chelsea McKibbon Haoyao Ruan Emma Mackay Natalie Dennis Russanthy Velummailum Philip He Yoko Tanaka Yan Xiong Aaron Springford Mats Rosenlund Source Type: research