Heat-Treatment Precipitates Latent Painful Neuropathy in Rats with Fabry Disease

Fabry disease is the most common lysosomal storage disorder —affecting as many as 1:1600 males—and arises from mutations in the X-linked gene GLA. Patients with Fabry disease develop painful small-fiber neuropathy during adolescence, which is accompanied by episodic pain that is induced by heat, fever, or exercise. While Gla-KO Fabry rats exhibit pain-li ke behaviors, they incompletely capture patient phenotypes and only develop robust sensory phenotypes later during their lifespan. To address this clinical-preclinical discrepancy, we asked whether early exposure to heat-stress could precipitate a latent painful neuropathy in young, presymptomatic F abry rats.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research