Identification Of Drug Treatments That Stimulate C-Fiber Regeneration

Small fiber neuropathy (SFN) is a widespread complication that leads to pain, burning, or loss of sensation in the distal limbs. A hallmark of SFN is a loss of intraepidermal nerve fibers (IENF). Currently, therapeutic options for humans with SFN are severely lacking. However, preclinical studies have identified numerous drugs that stimulate IENF regeneration in rodents but have not yet translated to human use. Here, we leveraged existing information from published articles to identify all drugs that have reported IENF regenerative effects in rodents.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research