C-Fiber Damage in a Mouse Model of Alzheimer's Disease

Nociceptors that innervate the epidermis convey afferent transmission of pain information. When damaged, c-fibers become sensitized and can increase spontaneous activity. Typically, pain is not thought of when studying Alzheimer ’s Disease (AD); however, 45% of AD patients have chronic pain, and widespread pain is associated with a 47% increase in Alzheimer’s disease dementia risk. To identify mechanisms of pain and c-fiber damage in AD, we are exploring the hypothesis that amyloid-beta accumulation is toxic to c-fibers via toll-like receptor(TLR)4/NF-kB signaling pathways.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research