Growth Hormone Regulates Neonatal Pain and Peripheral Inflammation Through STAT1 Dependent Transcription in Sensory Neurons

Neonatal pain is a significant clinical issue but the mechanisms by which pain is produced early in life are poorly understood. Our recent work has linked the transcription factor (TF) serum response factor downstream of local growth hormone (GH) signaling to incision-related hypersensitivity in neonates. However, it remains unclear if similar mechanisms contribute to inflammatory pain in neonates. Therefore, we investigated if distinct TFs or GH modulated nociceptive behaviors in neonates following hindpaw muscle inflammation using 1% carrageenan.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research