Genomic analysis and selective small molecule inhibition identifies BCL-X L as a critical survival factor in a subset of colorectal cancer

Conclusions:
This work demonstrates the utility of characterizing frequent genomic alterations to identify cancer survival genes. In addition, these studies demonstrate the utility of the highly potent and selective compound A-1155463 for investigating the role of BCL-X
L
in mediating the survival of specific tumor types, and indicate that BCL-X
L
inhibition could be an effective treatment for colorectal tumors with high BCL-X
L
and NOXA expression.

Source: Molecular Cancer - July 2, 2015 Category: Cancer & Oncology Authors: Haichao ZhangJohn XuePaul HesslerStephen TahirJun ChenSha JinAndrew SouersJoel LeversonLloyd Lam Source Type: research