Micelle formation of sodium taurolithocholate

This study investigated the aggregate properties of the NaTLC using surface tension measurements, light scattering, small-angle X-ray scattering (SAXS), and cryo-transmission electron microscopy (cryo-TEM). Surface tension measurement showed that the surface tension of the NaTLC solution decreased to 54 mN m-1. The concentration that showed the minimum surface tension corresponded to the critical micelle concentration (CMC: 0.6 mmol L-1, 308 K) determined by the change in light scattering intensity. On the other hand, the degree of counterion (sodium ions) binding to the micelles increased with increasing NaTLC concentration. SAXS and cryo-TEM measurements showed that the NaTLC formed large string-like micelles. The surface activity and large aggregates showed the potential for use as biosurfactants. However, because of the relatively low solubility of NaTLC in water, its use as a biosurfactant is limited to a narrow concentration range.PMID:38325711 | DOI:10.1016/j.chemphyslip.2024.105378
Source: Chemistry and Physics of Lipids - Category: Lipidology Authors: Source Type: research