Demographic characteristics and risk factors for invasive fungal sinusitis in the context of COVID-19: A systematic review and meta-analysis

Invasive fungal sinusitis (IFS) is a rare, life-threatening, and the most aggressive form of fungal infection. It is characterized by extensive tissue necrosis through vascular invasion and thrombosis, following by rapid progression and invasion into the orbit and brain from the nasal and sinus mucosa [1]. The leading pathogens are Aspergillus and mucor [2]. If not detected and treated early, the condition rapidly deteriorates, with the mortality rates as high as 50% to 80% due to intracranial extension, orbital involvement, and irreversible immunosuppression [3].
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research