Perinatal inflammation, fetal growth restriction, and long-term neurodevelopmental impairment in Bangladesh

CONCLUSIONS: In rural Bangladesh, perinatal inflammation was associated with impaired neurodevelopment at 24 months. The associations were strongest among SGA infants and noted across several biomarkers and domains, supporting the neurobiological role of inflammation in adverse fetal development, particularly in the setting of fetal growth restriction.IMPACT: Cord blood inflammation was associated with fine motor and language delays at 24 months of age in a community-based cohort in rural Bangladesh. 23.4 million infants are born small-for-gestational-age (SGA) globally each year. Among SGA infants, the associations between cord blood inflammation and adverse outcomes were strong and consistent across several biomarkers and neurodevelopmental domains (cognitive, motor, language), supporting the neurobiological impact of inflammation prominent in growth-restricted infants. Prenatal interventions to prevent intrauterine growth restriction are needed in low- and middle-income countries and may also result in long-term benefits on child development.PMID:38589559 | DOI:10.1038/s41390-024-03101-x

Source: Pediatric Research - April 8, 2024 Category: Pediatrics Authors: Anne Cc Lee Sara Cherkerzian Fahmida Tofail Lian V Folger Salahuddin Ahmed Sayedur Rahman Nabid H Chowdhury Rasheda Khanam Ingrid Olson Emily Oken Raina Fichorova Charles A Nelson Abdullah H Baqui Terrie Inder Source Type: research