Dual ‐Track Multifunctional Bimetallic Metal‐Organic Frameworks for Antibiotic Enrichment and Detection

The proposed approach in this study introduces a dual-track bimetallic metal –organic frameworks strategy aimed at achieving the enrichment, separation, and detection of antibiotics. Investigation into the mechanisms of various functionalities is conducted. This strategy is of paramount significance in the prevention and control of antibiotics and their derivatives' advers e effects. AbstractThe improper use and overuse of antibiotics have led to significant burdens and detrimental effects on the environment, food supply, and human health. Herein, a magnetic solid-phase extraction program and an optical immunosensor based on bimetallic Ce/Zr-UiO 66 for the detection of antibiotics are developed. A magnetic Fe3O4@SiO2@Ce/Zr-UiO 66 metal-organic framework (MOF) is prepared to extract and enrich chloramphenicol from fish, wastewater, and urine samples, and a horseradish peroxidase (HRP)-Ce/Zr-UiO 66@bovine serum protein-chloramphenicol probe is used for the sensitive detection of chloramphenicol based on the dual-effect catalysis of Ce and HRP. In this manner, the application of Ce/Zr-UiO 66 in integrating sample pretreatment and antibiotic detection is systematically investigated and the associated mechanisms are explored. It is concluded that Ce/Zr-UiO 66 is a versatile dual-track material exhibiting high enrichment efficiency (6.37  mg g−1) and high sensitivity (limit of detection of 51.3 pg mL−1) for chloramphenicol detection and serving as a multifunctional MOF for s...
Source: Small - Category: Nanotechnology Authors: Tags: Research Article Source Type: research