A Molecular Criteria for Antibody Mediated Rejection in Lung Transplant Recipients is Associated with an Increased Risk of the Composite Outcome of CLAD and Death

Purpose: Pulmonary antibody mediated rejection (AMR) is associated with chronic lung allograft dysfunction (CLAD) and death. The current International Society for Heart and Lung Transplantation (ISHLT) criteria for AMR is predicated on a constellation of clinical, laboratory and histopathological parameters, including the presence of donor-specific antibodies (DSA). The degree of allograft injury on the molecular level, as measured by donor-derived cell-free DNA (dd-cfDNA), is not considered in the ISHLT criteria but may identify patients experiencing a form of antibody mediated rejection.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research