Genome-Wide Molecular Analysis of Heart Transplant Endomyocardial Biopsies Separately Analyzing Rejection and Parenchymal Injury

Purpose: The Molecular Microscope ® Diagnostic System (MMDx) system for interpreting heart transplant endomyocardial biopsies (EMBs) currently uses expression of kidney-derived rejection-associated transcripts (RATs) to identify antibody-mediated and T cell-mediated rejection (ABMR, TCMR), but this also detects recent acute injury. We developed a new model to assess rejection and injury separately.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K.S. Madill-Thomsen, M. Mackova, A.Z. Aliabadi-Zuckermann, M. Cadeiras, M. Crespo-Leiro, M. Deng, J. Goekler, S. Hall, A. Jamil, D.H. Kim, J. Kobashigawa, P. MacDonald, J. Patel, L. Potena, K. Shah, J. Stehlik, A. Zuckermann Source Type: research