Long Term Outcome of First-Year C1q Positive Donor Specific Antibodies After Heart Transplantation

Purpose: Detection of donor specific antibodies (DSA) after heart transplantation (HTx) has been associated with poor outcome in the long term. DSA have been associated with decreased survival, increased incidence of cardiac allograft vasculopathy (CAV), increase in cardiac dysfunction, and increase in non-fatal major adverse cardiac events (NF-MACE). DSA are heterogeneous and amount of antibody-binding can be detected by the Luminex assay. Functional studies indicate whether the DSA can cause killing by the ability to bind complement.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Patel, M. Kittleson, M. Welton, N. Bhatnagar, A. Kanungo, M. Lee, Z. Wakefield, M. Hamilton, A. Hage, L. Czer, P. Catarino, J. Kobashigawa Source Type: research