Inhibition of ALOX12-12-HETE Alleviates Lung Ischemia Reperfusion Injury by Reducing Endothelial Ferroptosis-Mediated Neutrophil Extracellular Traps Formation

Purpose: Lung ischemia reperfusion injury (IRI) is a major cause of primary graft dysfunction after lung transplantation lacking effective treatment. Ferroptosis is a new type of cell death which is driven by iron-dependent lipid peroxidation. However, whether it is involved in lung IRI remains poorly understood.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , P. Gao, F. Zhuang, Z. Wang, Z. Zhou, G. Wu, T. Wang, C. Chen, J. Wu Source Type: research