IL-6 Blockade Promotes Tolerance of Heart but Not Lung Allografts in Non-Human Primate Simultaneous Organ and Bone Marrow Transplantation Protocols

Purpose: We previously achieved tolerance of heart allografts in non-human primates (NHPs) using IL-6 signaling blockade in a mixed-chimerism protocol where donor bone marrow transplantation (BMT) occurs simultaneously with solid organ transplantation. Here, we report the differential effect of adding aIL-6R mAb therapy to a simultaneous mixed-chimerism protocol for heart and lung transplantation.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J.T. Nawalaniec, J. O, A. Dehnadi, N. Hays, J. Muoio, C. Winter, I. Hanekamp, J. Madsen, J.S. Allan Source Type: research