Bronchoalveolar Lavage and Plasma Proteomes Identify Features of Disease That Segregate Lung Transplant Recipients with versus without Bronchiolitis Obliterans Syndrome

Purpose: Protein biomarkers of chronic lung allograft dysfunction (CLAD) can aid in early detection before clinical diagnosis and may shed light on the molecular underpinnings of disease. We hypothesized that determining proteomic differences in the bronchoalveolar lavage fluid (BALF) of LTx recipients with CLAD-bronchiolitis obliterans syndrome (BOS) phenotype versus no CLAD-BOS can identify disease-associated biomarkers and pathways and suggest therapeutic interventions.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research