Transient Heat Stress Protects from Endothelial Injury During Prolonged Ex-Vivo Perfusion of Warm Ischemic Rat Lungs

Purpose:: Ex-vivo lung perfusion (EVLP) is a validated technique allowing evaluation and reconditioning of lung graft before transplantation (LTx). Moderate hyperthermia is recognized to induces cytoprotective effect, by increased production of specific proteins, well known as heat shock proteins (HSPs). We hypothesized that moderate heat stress applied during EVLP could improve lung graft function in a prolonged ex-vivo perfusion model via reduction of lung endothelial permeability and inflammation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research