Developing a Multidimensional Immunological Toolset to Facilitate Rejection Diagnosis and Mechanistic Understanding of Chronic Lung Allograft Dysfunction After Human Lung Transplantation

Purpose: Rejection and infection are risk factors for chronic lung allograft dysfunction (CLAD) that limit lung transplantation (LuTx) success. Despite the importance of T cells in driving alloresponses and immune defense, the dynamic repopulation, clonal distribution, alloreactivity, and anti-microbial reactivity of T cells after LuTx are largely unknown.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , W. Jiao, K.D. Long, T. Young, C. Bay Muntnich, A. Prada Rey, K. Rogers, A. Valena, J. Costa, L. Benvenuto, J. Sonett, P. Lemaitre, F. D ’Ovidio, S. Arcasoy Source Type: research