Rationale, Design and Patient Characteristics from The DevelopmEnt of Non-Invasive Cell-Free DNA to Supplant INvasivE Biopsy in Heart Transplantation (DEFINE-HT) Study

Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a non-invasive biomarker of cardiac allograft injury including cellular or antibody mediated rejection after heart transplant (HTx) with the potential to reduce the need for invasive surveillance endomyocardial biopsies. Current reports of dd-cfDNA in HTx are limited to case series or cross-sectional studies with patients enrolled at different time points post-HTx. Therefore, longitudinal data analysis among diverse patients followed from the time of transplant and during the early post-transplant period could inform more optimal use of dd-cfDNA.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K.H. Schlendorf, P.J. Kim, J.L. Kennedy, O. Wever-Pinzon, J.N. Nativi Nicolau, E. Hsich, M.M. Givertz, A.D. DeVore, K. Ghafourian, E. Kransdorf, J. Patel, M.M. Colvin, H.J. Eisen, K. Marshall, S. Carey, M. Olymbios, M.R. Mehra, J. Stehlik Source Type: research