A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells

CONCLUSIONS: BET inhibitors specifically target p60AmotL2-expressing invasive cancer cells, likely by exploiting differences in chromatin accessibility, leading to cell death. Additionally, our findings support the use of this phenotypic strategy to discover novel compounds that can exploit vulnerabilities and specifically target invasive cancer cells.PMID:38594748 | PMC:PMC11003180 | DOI:10.1186/s13046-024-03031-w

Source: Clinical Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Pedro Fonseca Weiyingqi Cui Nona Struyf Le Tong Ayushi Chaurasiya Felipe Casagrande Honglei Zhao Dinura Fernando Xinsong Chen Nicholas P Tobin Brinton Seashore-Ludlow Andreas Lundqvist Johan Hartman Anita G öndör P äivi Östling Lars Holmgren Source Type: research