Immune Activation in Alzheimer Disease
We describe how brain-resident macrophages, the microglia, are able to detect Aβ species and be activated, as well as the consequences of activated microglia in AD pathogenesis. We discuss transcriptional changes of microglia in AD, their unique heterogeneity in humans, and emerging strategies to study human microglia. Finally, we expose, beyond Aβ and microglia, the role of peripheral signals and different cell types in immune activation. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.PMID:38424470 | DOI:10.1146/annurev-immunol-101921-035222
Source: Annual Review of Immunology - Category: Allergy & Immunology Authors: Arnaud Mary Renzo Mancuso Michael T Heneka Source Type: research