Pulmonary Hypertension in Women

Methodist Debakey Cardiovasc J. 2024 Mar 14;20(2):70-80. doi: 10.14797/mdcvj.1308. eCollection 2024.ABSTRACTPulmonary arterial hypertension (PAH) is a rare devastating disease characterized by elevated pulmonary artery pressure and increased pulmonary vascular resistance. Females have a higher incidence of PAH, which is reflected globally across registries in the United States, Europe, and Asia. However, despite female predominance, women had better outcomes compared with male patients, a finding that has been labeled the "estrogen paradox." Special considerations should be given to women with PAH regarding sexual health, contraception, family planning, and treatment before, during, and after pregnancy. Pregnant women with PAH should be referred to a pulmonary hypertension care center; a multidisciplinary team approach is recommended, and Cesarean section is the preferred mode of delivery. While pregnancy outcomes have improved over the years with PAH-specific therapy, pregnancy portends a high-risk for those with PAH. Continued research is needed to tailor PAH treatment for women.PMID:38495664 | PMC:PMC10941702 | DOI:10.14797/mdcvj.1308
Source: Methodist DeBakey Cardiovascular Journal - Category: Cardiology Authors: Source Type: research