Chemical constituents of the aerial parts of < em > Mitracarpus hirtus < /em > (L.) DC (Rubiaceae)

Nat Prod Res. 2024 Apr 8:1-7. doi: 10.1080/14786419.2024.2337110. Online ahead of print.ABSTRACTA phytochemical investigation of the aerial parts of Mitracarpus hirtus afforded thirteen compounds, including a new naphthoquinone di-glycoside (1), three isopentenyl isoflavones (2-4), four flavonoids (5-8), three iridoid glycosides (9 - 11) and two coumarins (12 and 13). Their structures were elucidated based on extensive spectroscopic analyses, chemical methods, and the comparison with the literature. Among them, compound 1 possesses a 2-(3-methylnaphthalen-2-yl)acetic acid core with two glucosyl groups, compounds 2-4 are the first three representatives from the Rubiaceae family, and compounds 9-11 and 13 were isolated from Mitracarpus genus for the first time. Additionally, compounds 2-4 displayed potent antibacterial activities against Helicobacter pylori G27/HP159/JRES00015 (MIC = 4-16 μg/mL) , comparable to metronidazole. To date, wighteone (2) is the most active isoflavone with favourable predicted ADMET properties reported against H. pylori.PMID:38586937 | DOI:10.1080/14786419.2024.2337110
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research