Discovery of olimycin E from < em > Streptomyces < /em > sp. 11695

Nat Prod Res. 2024 Apr 8:1-6. doi: 10.1080/14786419.2024.2337131. Online ahead of print.ABSTRACTA new natural product olimycin E (1), together with two known compounds of divergolide R (2) and olimycin B (3), were obtained from the marine-derived Streptomyces sp. 11695. The structures of 1-3 were established on the basis of HRESIMS as well as 1D and 2D NMR datasets. The absolute configuration of 1 is identified as 4 R, 6S, 7S, 10 R by comparison the experiment ECD with that of the theoretical ECD. Antibacterial results showed that compound 2 have antibacterial activities against Staphylococcus aureus and MRSA with the MIC values of 32 μg/mL, respectively.PMID:38586959 | DOI:10.1080/14786419.2024.2337131
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research