Cancers, Vol. 16, Pages 1437: Clinical [18F]FSPG Positron Emission Tomography Imaging Reveals Heterogeneity in Tumor-Associated System xc & minus; Activity
Conclusion: [18F]FSPG PET/CT imaging from both NSCLC and HNSCC cohorts showed the same normal-tissue biodistribution, but marked tumor heterogeneity across subjects and between lesions. Despite rapid elimination through the urinary tract and low normal-background tissue retention, the diagnostic potential of [18F]FSPG was limited by variability in tumor retention. As [18F]FSPG retention is mediated by the tumor’s antioxidant capacity and response to oxidative stress, this heterogeneity may provide important insights into an individual tumor’s response or resistance to therapy.
Source: Cancers - Category: Cancer & Oncology Authors: Amy R. Sharkey Norman Koglin Erik S. Mittra Sangwon Han Gary J. R. Cook Timothy H. Witney Tags: Article Source Type: research
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