Early molecular events of autosomal-dominant Alzheimer's disease in marmosets with PSEN1 mutations

We report the successful generation of genetically engineered marmosets harboring knock-in point mutations in the PSEN1 gene. PSEN1 marmosets and their germline offspring recapitulate the early emergence of AD-related biomarkers. Studies as early in life as possible in PSEN1 marmosets will enable the identification of primate-specific mechanisms that drive disease progression.PMID:38574388 | DOI:10.1002/alz.13806

https://pubmed.ncbi.nlm.nih.gov/38574388/?utm_source=no_user_agent&utm_medium=rs...

Source: The Journal of Alzheimers Association - April 4, 2024 Category: Psychiatry Authors: Gregg E Homanics Jung Eun Park Lauren Bailey David J Schaeffer Lauren Schaeffer Jie He Shuoran Li Tingting Zhang Annat Haber Catrina Spruce Anna Greenwood Takeshi Murai Laura Schultz Lauren Mongeau Seung-Kwon Ha Julia Oluoch Brianne Stein Sang Ho Choi Has Source Type: research