Dysregulation of kidney proteases in the pathogenesis of hypertension following unilateral nephrectomy in juvenile mice

CONCLUSION: UNX results in the development of persistent and progressive hypertension. Down-regulation of KLK1 and up-regulation of various cathepsins may contribute to the development of hypertension via multiple mechanisms including a decrease in nitric oxide (NO) production.PMID:38463588 | PMC:PMC10918144 | DOI:10.62347/HONT9617
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research