Bcat2 ‐Mediated Branched‐Chain Amino Acid Catabolism Is Linked to the Aggravated Inflammation in Obese with Psoriasis Mice

Conclusion: HFD-induced obesity significantly amplifies IL-17 signaling and exacerbates psoriasis, with a potential role played by Bcat2-mediated BCAAs metabolism. The study suggests that BCAA catabolism and PPAR γ-STAT3 exacerbate inflammation in psoriasis with obesity.

https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202300720?af=R

Source: Molecular Nutrition and Food Research - April 6, 2024 Category: Food Science Authors: Yazhuo Wang, Ning Zhao, Yujiao Meng, Jia Chen, Cong Qi, Xueqing Hu, Haoyue Zhu, Danyang Yang, Xiawei Zhang, Huike Ma, Jingxia Zhao, Tingting Di, Ping Li, Yan Wang Tags: Research Article Source Type: research