Does female sex matter in a chronic intermittent hypoxia mouse model?

Intermittent hypoxia (IH) occurs in patients with obstructive sleep apnea, where periods of hypoxia alternate with periods of normoxia, leading to cardiovascular damage [1]. Indeed, IH induces oxidative stress and systemic inflammation through the activation of hypoxia inducible factor 1 subunit alpha (HIF α), nuclear factor kappa-B (NFκB) and toll like receptor 4 (TLR4), which contribute to accelerated atherosclerosis development [2]. To study the development of atherosclerotic lesions under chronic intermittent hypoxia (CIH) in vivo, the majority of researchers have used a male ApoE−/− mouse m odel.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research