Recent advances in age-related metabolic dysfunction-associated steatotic liver disease

World J Gastroenterol. 2024 Feb 21;30(7):652-662. doi: 10.3748/wjg.v30.i7.652.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 25% of the world's population and has become a leading cause of chronic liver disease. In recent years, an increasing amount of data suggests that MASLD is associated with aging. As the population ages, age-related MASLD will become a major global health problem. Targeting an aging will become a new approach to the treatment of MASLD. This paper reviews the current studies on the role of aging-related factors and therapeutic targets in MASLD, including: Oxidative stress, autophagy, mitochondrial homeostasis, bile acid metabolism homeostasis, and dysbiosis. The aim is to identify effective therapeutic targets for age-related MASLD and its progression.PMID:38515956 | PMC:PMC10950625 | DOI:10.3748/wjg.v30.i7.652
Source: World Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research