Metformin Suppresses Both PD-L1 Expression in Cancer Cells and Cancer-Induced PD-1 Expression in Immune Cells to Promote Antitumor Immunity

CONCLUSIONS: Metformin blocks both PD-L1 and PD-1 within the tumor microenvironment. This study provided a mechanistic insight into the efficacy of metformin in improving immunotherapy in human cancer.PMID:38529546 | DOI:10.3343/alm.2023.0443
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Authors: Source Type: research