Cognition after a 4-week high phenylalanine intake in adults with phenylketonuria - a randomized controlled trial

CONCLUSIONS: In early-treated adult patients with PKU, a 4-week high Phe intake was noninferior to continuing Phe restriction regarding working memory accuracy, and secondary outcomes did not differ except for sustained attention. Longer-term RCTs are required to determine whether low Phe levels need to be maintained throughout different periods of adulthood. This trial was registered at the clinicaltrials.gov as NCT03788343.PMID:38569786 | DOI:10.1016/j.ajcnut.2023.11.007

Source: The American Journal of Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Roman Trepp Raphaela Muri Stephanie Maissen-Abgottspon Alan G Haynes Michel Hochuli Regula Everts Source Type: research