Cancers, Vol. 16, Pages 1410: Early-Stage Non-Small Cell Lung Cancer: Prevalence of Actionable Alterations in a Monocentric Consecutive Cohort

Cancers, Vol. 16, Pages 1410: Early-Stage Non-Small Cell Lung Cancer: Prevalence of Actionable Alterations in a Monocentric Consecutive Cohort Cancers doi: 10.3390/cancers16071410 Authors: Rossella Bruno Anello Marcello Poma Martina Panozzi Alessandra Lenzini Gianmarco Elia Carmelina Cristina Zirafa Vittorio Aprile Marcello Carlo Ambrogi Editta Baldini Marco Lucchi Franca Melfi Antonio Chella Andrea Sbrana Greta Alì Early-stage (ES) non-small cell lung cancer (NSCLC) is diagnosed in about 30% of cases. The preferred treatment is surgery, but a significant proportion of patients experience recurrence. Neoadjuvant and adjuvant chemotherapy has a limited clinical benefit. EGFR tyrosine kinase inhibitors and immunotherapy have recently opened new therapeutic scenarios. However, only a few data are available about the ES-NSCLC molecular landscape and the impact of oncogene addiction on therapy definition. Here, we determined the prevalence of the main lung cancer driver alterations in a monocentric consecutive cohort. Molecular analysis was performed on 1122 cases, including 368 ES and 754 advanced NSCLC. The prevalence of actionable alterations was similar between early and advanced stages. ES-NSCLC was significantly enriched for MET exon-14 skipping alterations and presented a lower prevalence of BRAF p.(V600E) mutation. PD-L1 expression levels, evaluated according to actionable alterations, were higher in advanced than early tumors harboring E...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research