Viruses, Vol. 16, Pages 559: Measles Virus-Based Vaccine Expressing Membrane-Anchored Spike of SARS-CoV-2 Inducing Efficacious Systemic and Mucosal Humoral Immunity in Hamsters
Viruses, Vol. 16, Pages 559: Measles Virus-Based Vaccine Expressing Membrane-Anchored Spike of SARS-CoV-2 Inducing Efficacious Systemic and Mucosal Humoral Immunity in Hamsters
Viruses doi: 10.3390/v16040559
Authors:
Zhi-Hui Yang
Yan-Li Song
Jie Pei
Song-Zhuang Li
Rui-Lun Liu
Yu Xiong
Jie Wu
Yuan-Lang Liu
Hui-Fen Fan
Jia-Hui Wu
Ze-Jun Wang
Jing Guo
Sheng-Li Meng
Xiao-Qi Chen
Jia Lu
Shuo Shen
As SARS-CoV-2 continues to evolve and COVID-19 cases rapidly increase among children and adults, there is an urgent need for a safe and effective vaccine that can elicit systemic and mucosal humoral immunity to limit the emergence of new variants. Using the Chinese Hu191 measles virus (MeV-hu191) vaccine strain as a backbone, we developed MeV chimeras stably expressing the prefusion forms of either membrane-anchored, full-length spike (rMeV-preFS), or its soluble secreted spike trimers with the help of the SP-D trimerization tag (rMeV-S+SPD) of SARS-CoV-2 Omicron BA.2. The two vaccine candidates were administrated in golden Syrian hamsters through the intranasal or subcutaneous routes to determine the optimal immunization route for challenge. The intranasal delivery of rMeV-S+SPD induced a more robust mucosal IgA antibody response than the subcutaneous route. The mucosal IgA antibody induced by rMeV-preFS through the intranasal routine was slightly higher than the subcutaneous route, but there was no significant difference. The rMeV-preFS vaccine stim...
Source: Viruses - Category: Virology Authors: Zhi-Hui Yang Yan-Li Song Jie Pei Song-Zhuang Li Rui-Lun Liu Yu Xiong Jie Wu Yuan-Lang Liu Hui-Fen Fan Jia-Hui Wu Ze-Jun Wang Jing Guo Sheng-Li Meng Xiao-Qi Chen Jia Lu Shuo Shen Tags: Article Source Type: research
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