The Complementary Roles of Iron and Estrogen in Menopausal Differences in Cardiometabolic Outcomes

Biological hormonal changes are frequently cited as an explanatory factor of sex and menopause differences in cardiometabolic diseases (CMD) and its associated risk factors. However, iron metabolism which varies between sexes and among women of different reproductive stages could also play a role. Recent evidence suggest that iron may contribute to CMD risk by modulating oxidative stress pathways and inflammatory responses, offering insights into the mechanistic interplay between iron and CMD development.

Source: Clinical Nutrition - April 3, 2024 Category: Nutrition Authors: Noushin Sadat Ahanchi, Farnaz Khatami, Erand Llanaj, Hugo G. Quezada-Pinedo, Helga Dizdari, Arjola Bano, Marija Glisic, Michele F. Eisenga, Pedro-Marques Vidal, Taulant Muka Tags: Narrative Review Source Type: research