A Multilayered Post –Genome‐Wide Association Study Analysis Pipeline Defines Functional Variants and Target Genes for Systemic Lupus Erythematosus

ConclusionWe demonstrate and validate post-GWAS strategies for using multidimensional data to prioritize likely causal variants with cognate gene targets underlying SLE pathogenesis. Our results provide a catalog of significantly SLE-associated SNPs and loci, target genes, and likely biochemical mechanisms to guide experimental characterization.

https://onlinelibrary.wiley.com/doi/10.1002/art.42829?af=R

Source: Arthritis and Rheumatology - March 27, 2024 Category: Rheumatology Authors: Mehdi Fazel ‐Najafabadi, Loren L. Looger, Harikrishna Reddy Rallabandi, Swapan K. Nath Tags: Full Length Source Type: research