Clinical translation of a novel FAPI dimer [68Ga]Ga-LNC1013

ConclusionDimerization is an effective strategy to produce FAPI derivatives with favorable tumor uptake, long tumor retention, and imaging contrast over its monomeric counterpart. We demonstrated that [68Ga]Ga-LNC1013, the lead compound without any piperazine moiety, had superior diagnostic potential over [68Ga]Ga-FAPI-46 and18F-FDG, suggesting the future potential of LNC1013 for radioligand therapy of FAP-positive cancers.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research