Heterogeneity in elevated glucose and A1C as predictors of the prediabetes to diabetes transition: Framingham Heart Study, Multi-Ethnic Study on Atherosclerosis, Jackson Heart Study, and Atherosclerosis Risk In Communities

CONCLUSION: The absolute transition rate from prediabetes to diabetes significantly depends on both cohort and prediabetes definitions.RESEARCH IN CONTEXT: What is already known about this subject? The prevalence of prediabetes and the transition rate to diabetes vary significantly across different populations and are influenced by the diagnostic criteria used, such as fasting glucose levels and HbA1C percentages.Definitions of prediabetes by organizations like the American Diabetes Association (ADA) and World Health Organization (WHO) influence the estimation of diabetes transition risk.Previous studies have shown a wide range of diabetes transition rates from prediabetes, implying potential heterogeneity in risk assessments across different cohorts. What is the key question? How does the heterogeneity in diabetes transition rates from prediabetes across different glycemic definitions affect our understanding and management of the risk in major US cohorts? What are the new findings? There is substantial heterogeneity in diabetes transition rates across different US cohorts and prediabetes definitions, with large prediction intervals.Obesity and hypertension do not account for the differences in transition risk, suggesting other between cohort factors are at play. How might this impact clinical practice in the foreseeable future? Understanding the variability in diabetes transition rates across different populations and definitions is important for planning for precision medi...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research