CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation

CONCLUSIONS: Distinct from its canonical function in strengthening cell adhesion at cell surface, CD151 maintains endolysosome function by sustaining VCP/p97-mediated protein unfolding and turnover. By supporting protein quality control and protein degradation, CD151 prevents proteins from (1) buildup in endolysosomes and (2) discharge through exosomes, to limit vascular inflammation. Also, our study conceptualizes that balance between degradation and discharge of proteins in endothelial cells determines vascular information. Thus, the IFITM3/V-ATPase-tetraspanin-VCP/p97 complexes on endolysosome, as a protein quality control and inflammation-inhibitory machinery, could be beneficial for therapeutic intervention against vascular inflammation.PMID:38557119 | DOI:10.1161/CIRCRESAHA.123.323190

Source: Circulation Research - April 1, 2024 Category: Cardiology Authors: Junxiong Chen Yingjun Ding Chao Jiang Rongmei Qu Jonathan D Wren Constantin Georgescu Xuejun Wang Darlene N Reuter Beibei Liu Cory B Giles Christoph H Mayr Herbert B Schiller Jingxing Dai Christopher S Stipp Bharathiraja Subramaniyan Jie Wang Houjuan Zuo Source Type: research