The dysfunction of CD8 < sup > + < /sup > T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis

In conclusion, this study revealed the global cellular variation of endometriosis among which the cellular count and physiology of EMCs and T cells were significantly changed. The depressed cytotoxicity and aberrant metabolism of CD8+ T cells were induced by ESCs with the activation of STAT1/PDCD1 pathway resulting in immune survival to promote endometriosis.PMID:38544333 | DOI:10.1111/imm.13786

Source: Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Zhi-Xiong Huang Dian-Chao Lin Hua-Ying Zhang Meng-Jie Yang Jia-Hao Chen Xin-Yu Ding Song-Juan Dai Yi-Huang Hong Gui-Shuang Liang Qi-Yuan Li Qiong-Hua Chen Source Type: research