Tumor analysis of MMR genes in Lynch ‐like syndrome: Challenges associated with results interpretation

DiscussionMore biallelic somatic events were identified at VAF  ≥ 5% than ≥10% (35.9% vs. 25.6%), although the rate of nonconcordant results regarding immunohistochemical pattern increased (30.8% vs. 20.5%). Interpretation difficulties question the current utility of the identification of MMR somatic hits in the diagnostic algorithm of suspected LS case s.

Source: Cancer Medicine - April 1, 2024 Category: Cancer & Oncology Authors: Paula Rofes, N úria Dueñas, Jesús del Valle, Matilde Navarro, Judith Balmaña, Teresa Ramón y Cajal, Noemí Tuset, Carmen Castillo, Sara González, Joan Brunet, Gabriel Capellá, Conxi Lázaro, Marta Pineda Tags: RESEARCH ARTICLE Source Type: research