The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes

DISCUSSION: In this review we describe the role of TAU isoforms in health and disease, and stress the importance of comprehending and studying TAU isoforms in both, physiological and pathological context, in order to develop targeted therapeutic interventions for TAU-associated diseases.HIGHLIGHTS: MAPT splicing is tightly regulated during neuronal maturation and throughout life. TAU isoform expression is development-, cell-type and brain region specific. The contribution of TAU to neurodegeneration might be isoform-specific. Ineffective TAU-based therapies highlight the need for specific targeting strategies.PMID:38556838 | DOI:10.1002/alz.13784
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Source Type: research